reMYND raises 12 million EUR to assess clinical proof-of-mechanism in Alzheimer’s and to expand into orphan disorders


Leuven Belgium, December 18th, 2018: reMYND NV announced today the closing of a
12 million EUR financing round to
• advance its Alzheimer program into clinical testing and assess its novel
mechanism in patients;
• broaden the pipeline into CNS orphan programs, including Huntington and ALS;
• further innovate and expand the service offering of its CRO; and
• strengthen the executive team and board.

Based on its proprietary phenotypic screening platform, reMYND develops novel
curative treatments against Alzheimer’s, diabetes, and orphan protein-misfolding
disorders to tackle these diseases at the root rather than managing only the symptoms.

reMYND’s lead Alzheimer’s program ReS19 combines fast cognitive restoration with
protection against loss of neurons. The clinical candidate has been selected, scaled-up
its production and is currently in the last stages of pre-clinical testing before clinical
evaluation.

At the end of 2017, reMYND entered into a strategic collaboration with Novo Nordisk on
reMYND’s diabetes program ReS39 aimed at restoring insulin production in diabetes
animal models. Novo Nordisk has now decided to take this program in-house and to
move the lead into the last stages of pre-clinical testing.

reMYND’s 2nd Alzheimer program counteracts neuronal excitability and its novel target
has been featured in a high-profile publication. The clinical candidate is currently being
selected.

During 2018, reMYND has leveraged its proprietary discovery platform to identify novel
treatments against Huntington, further extending into Amytrophic Lateral Sclerosis
(ALS) and other CNS orphan disorders.

In order to advance these programs and broaden its portfolio, reMYND has closed a
financing round of 12 million EUR, co-led by PMV and Korys, with participation of the
existing shareholders including BNP Paribas Fortis Private Equity, KU Leuven, Gemma-
Frisius Fund and Dr. Bernard Majoie of Fondation Fournier-Majoie. Christoph Waer of
Korys will join amongst others Chris De Jonghe of PMV, Ajit Shetty, Rudy Dekeyser and
Paul Van Dun in reMYND’s board. Together with the annually recurring proceeds of
reMYND’s service business, grants and collaboration, these funds will allow reMYND to
advance its Alzheimer program into clinical testing and to assess its novel mechanism
in patients, whilst broadening the pipeline of CNS orphan programs, expanding the
service offering of its CRO and strengthening the executive team and board.


About reMYND
reMYND NV, founded in 2002 as a spin-off from the University of Leuven, drives the
development of disease-modifying treatments against Alzheimer’s, Parkinson’s,
diabetes, and other orphan protein misfolding disorders. To fulfil this mission reMYND
is organised as two independently managed business entities entailing a Drug Discovery
& Development unit and the Contract Research Organization (CRO).

reMYND’s most advanced own program, ReS19, restores calcium homeostasis in
Alzheimer’s, a process central in the disease cascade leading to neuronal demise and
build-up of plaques and tangles. By targeting the disease in its tracks, ReS19 combines
the best of both worlds: delivering a more robust immediate symptomatic benefit on
synaptic plasticity, cognition and cerebrospinal biomarkers, while in the longer-term
preventing build-up of plaques and neuronal loss.

reMYND’s diabetes program ReS39 sustains and increases the endogenous insulin
production capacity and insulin signalling in animal models of diabetes, providing fast
symptomatic relief combined with durability. In addition, ReS39 reduces liver weight
and its triglyceride content, making it potentially also relevant for NASH and the
metabolic syndrome. The program has previously shown a similar protective effect on
dopamine producing neurons in Parkinson’s mice, the most common motor disorder.

In addition, reMYND’s in-vivo Contract Research Organization (CRO) helps its clients to
assess the pharmacokinetics, -dynamics and efficacy of their experimental treatments
against Alzheimer's disease in reMYND’s proprietary mouse models. Our mission is to
be a strategic partner for our clients and help them identify the most promising set-up
to assess potential effects. Given the extensive experience fully focused on Alzheimer's
disease, reMYND’s CRO can contribute its expertise for every type of Alzheimer
treatment in any form of application. The CRO is serving 6 of the top 10 pharmaco’s
worldwide and its client-base covers the US, Europe and Japan. The CRO has provided
in-vivo proof-of-concept data for several candidate drugs that reMYND’s clients
currently have in clinical development.

reMYND has been substantially supported by grants from VLAIO/IWT (Flanders,
Belgium) and from the Michael J Fox Foundation.

For more information, contact reMYND at info@remynd.com, + 32 16 75 14 20 or
visit www.remynd.com

About Korys

Korys is a family-owned holding company that on the one hand focuses on direct investments in non-listed companies, and on the other hand also manages a portfolio of listed investments. Today, it has more than EUR 4 billion of assets under management, among which a significant participation in Colruyt Group, a leading retail company in Belgium and France. Investment decisions are taken with a long-term perspective on the basis of economic, ecological and social merit. Korys aims to create sustainable value through a diversified portfolio of investments and focuses on investment themes in which it has built substantial expertise, such as “Conscious Consumer”, “Medical Revolution”, “Energy Transition”, “Leadership in Retail”, “Resource Revolution” and “Future-proof Real Estate”. Korys has a team of more than 20 professionals based in Belgium and Luxembourg.

Contact Korys: Christoph Waer - christoph.waer@korys.be